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ChemInform Abstract: Symmetrical Bis(heteroarylmethoxyphenyl)alkylcarboxylic Acids as Inhibitors of Leukotriene Biosynthesis.
First published: 31 May 2010
Abstract
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ChemInform Abstract
Sodium salt (Ic) is selected from a series of title compounds, e.g. (I) and (II), as drug candidate with the best leukotriene inhibition and good oral bioavailability. The mode of inhibitory action occurs at the stage of 5-lipoxygenase biosynthesis as it blocks both leukotriene pathways leading to LTB4 and LTC4 but not PGH2 biosynthesis.
