Preparative Organic Chemistry
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ChemInform Abstract: Generation of Metalloenamines by Carbon—Carbon Bond Formation: Ring Opening Reactions of 2-Methyleneaziridines with Organometallic Reagents.
First published: 31 May 2010
Abstract
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ChemInform Abstract
Treatment of 2-methyleneaziridines such as (I) with Grignard reagents in the presence of Cu(I) results in a regioselective ring-opening furnishing metalloenamines of type (III), which immediately react with electrophiles to produce ketones (V) (6 examples).
