Physical Organic Chemistry
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ChemInform Abstract: Synthesis and Reactions of Biginelli Compounds. Part 19. X-Ray Structure, Conformational Analysis, Enantioseparation, and Determination of Absolute Configuration of the Mitotic Kinesin Eg5 Inhibitor Monastrol.
First published: 07 June 2010
Abstract
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ChemInform Abstract
Computational, X-ray diffraction, and NMR studies show that monastrol (I) is a conformationally mobile heterocyclic system with no clear preference for one of the four distinct conformers. Resolution of the racemate is achieved by direct enantioselective HPLC. The absolute configuration of the first eluting (S)-(+)-enantiomer is established by CD spectroscopy.
