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ChemInform Abstract: Enzyme-Assisted Asymmetric Total Synthesis of (-)-Podophyllotoxin and (-)-Picropodophyllin.
First published: 08 June 2010
Abstract
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ChemInform Abstract
The key steps in the synthesis of the title compounds are stereoselective formation of the meso diester (V), enzymatic desymmetrization of the meso diacetate (VI), and stereoselective introduction of the (3,4,5-trimethoxy)phenyl group.
