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ChemInform Abstract: Synthesis of a Model 22-Membered AB-C-O-D Ring of Vancomycin Containing Biaryl and Biaryl Ether Linkages.
First published: 08 June 2010
Abstract
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ChemInform Abstract
A fundamentally new strategy for the construction of the AB-C-O-D ring of vancomicin is described. Thus, cycloetherification of (II) gives the 22-membered macrocycle (III) with an endo aryl-aryl ether linkage and a biaryl bond. A transannular cycloamidation for the construction of the bicyclic precursor for vancomycin is planned.
