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ChemInform Abstract: Synthesis of Isothiochroman 2,2-Dioxide and 1,2-Benzooxathiin 2,2-Dioxide Gyrase B Inhibitors.
First published: 08 June 2010
Abstract
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ChemInform Abstract
Synthesis and in vitro biological evaluation of the title compounds (VII) and (XIII) is described. Compared to coumarin derivatives compound (XIII) exhibits improved inhibitory potency in negative supercoiling of relaxed DNA gyrase.
