Volume 31, Issue 23
Natural Products
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ChemInform Abstract: Synthesis of N-(Hydroxy)amide- and N-(Hydroxy)thioamide-Containing Peptides.

Lu Wang

Lu Wang

Dep. Chem., Univ. Cent. Fla., Orlando, FL 32816, USA

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Otto Phanstiel IV

Otto Phanstiel IV

Dep. Chem., Univ. Cent. Fla., Orlando, FL 32816, USA

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First published: 08 June 2010

Abstract

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ChemInform Abstract

A new technology for the introduction of either N-hydroxyamide or N-(hydroxy)thioamide linkages into pseudopeptide chains without racemization involving the coupling of N-(benzoyloxy)amines with Fmoc-protected amino acid derivatives [→(III)] as the crucial step is developed.

chemical structure image

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