ChemInform Abstract: Benzyl Derivatives of 2,1,3-Benzo- and Benzothieno[3,2-a]thiadiazine 2,2-Dioxides: First Phosphodiesterase 7 Inhibitors.
Abstract
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ChemInform Abstract
Synthesis, biological evaluation, and structure—activity relationships of a new family of thiadiazine dioxides is described. The biological data reveal that these compounds represent the first heterocyclic family of compounds with PDE 7 inhibitory properties appearing to be a new objective for the treatment of T-cell-dependent disorders. The benzothienothiadiazine moiety [cf. compounds (IV)] shows a slight increase in the inhibitory enzyme potency compared to the benzothiadiazine [cf. (VII)].
