Volume 31, Issue 23
Preparative Organic Chemistry
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ChemInform Abstract: Synthesis of Indan-Based Unusual α-Amino Acid Derivatives under Phase-Transfer Catalysis Conditions.

Sambasivarao Kotha

Sambasivarao Kotha

Dep. Chem., Indian Inst. Technol., Bombay 400 076, India

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Enugurthi Brahmachary

Enugurthi Brahmachary

Dep. Chem., Indian Inst. Technol., Bombay 400 076, India

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First published: 08 June 2010

Abstract

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ChemInform Abstract

Esters (IV) of conformationally constrained cyclic α-amino acids are readily available by PTC-catalyzed reaction of dibromides (I) with ethyl isocyanoacetate (II) and subsequent solvolysis of the resulting isonitriles (III).

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