ChemInform Abstract: Studies of Muscarinic Receptor Agonists: 2-(1-Methyl-1,2,3,6-Tetrahydropyridin-4-yl)benzoxazoles/benzothiazole.
Abstract
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ChemInform Abstract
Condensation of 4-pyridinecarboxaldehyde (I) with p-substituted o-aminophenols (II) or o-aminothiol (V) gives the corresponding Schiff′s bases, which are stable and can be isolated but are directly transformed by oxidative intramolecular cyclization in a one-pot process to give compounds (III) and (VI), respectively. Their partially hydrated derivatives (IV) and (VII) as well as their appropriate hydrochloride salts are examined for their binding affinities to the M1 subtype of muscarinic receptor by the [3H]-NMS binding assay.
