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ChemInform Abstract: Studies on Pyrrolidinone. Synthesis of Aza Analogues of Podophyllotoxin and Related Compounds.
First published: 09 June 2010
Abstract
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ChemInform Abstract
The Friedel—Crafts cyclization of N-benzhydrylpyroglutamic acids whose aromatic rings are substituted by methoxy or methylenedioxy groups provides access to podophyllotoxin analogues [cf. (IV), (VI)—(X)] whose lactone ring is changed to a lactam.
