ChemInform Abstract: Novel 3-Aminomethyl- and 4-Aminopiperidine Analogues of 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: Synthesis and Evaluation as Dopamine Transporter Ligands.
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract
Investigation of a series of title compounds, e.g. (I)—(IV), concerning their substituent effects on cocaine binding and neurotransmitter reuptake, shows that although compound (Ib) exhibits the highest ratio of dopamine reuptake inhibition to binding it does not demonstrate cocaine antagonist effects in vitro. Compound (Ib) is selected for further evaluation, but additional modifications are necessary for development as cocaine antagonist.
