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ChemInform Abstract: The Triumph of Zinc: A Short and Highly Efficient Synthesis of the Calyculin C1—C9 Tetraene Building Block by Negishi Coupling.
First published: 09 June 2010
Abstract
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ChemInform Abstract
Based on a highly efficient Negishi coupling of a bismetallic vinylzinc species (derived from trans-1,2-bis(tributylstannyl)ethene (I) by lithiation and transmetalation) with the bromo ester (II), a short and efficient synthesis of the phosphonate (IV), a key building block of the C1—C9 fragment of calyculins, is achieved.
