ChemInform Abstract: New N1-Hetarylmethylene-Substituted Amidrazones with Potential Antimycobacterial Activity.
Abstract
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ChemInform Abstract
Amidrazones combining the structural moiety of an N1-methylene-substituted amidrazone and some promising hetarylic substituents, which display antimycobacterial activity in previously synthesized amidrazones, are synthesized and tested against various mycobacterial strains. An alternative approach to amidrazones (X) resembles the multistep reaction for 2-benzoxazolylcarbaldoxime. Here, hydroxylamine can be replaced by pyrazinecarboxamidrazone (Ib) to give the amidrazones (X). Amidrazone (V) is obtained as a pure isomer; its structure is investigated using X-ray diffraction studies. None of the new compounds reveals any remarkable antimycobacterial activity.
