Heterocyclic Compounds
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ChemInform Abstract: A Novel Class of Na+ and Ca2+ Channel Dual Blockers with Highly Potent anti-Ischemic Effects.
First published: 10 June 2010
Abstract
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ChemInform Abstract
The synthesis of novel arylpiperidines (IV) and (VI) which exhibit highly potent blocking effects for both neuronal Na+ and Ca++ channels with extremely low affinity for dopamine D2 receptors is reported. Among these compounds the piperidine (VIa) exhibits remarkable neuroprotective activity.
