Heterocyclic Compounds
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ChemInform Abstract: Guanidine-Substituted Imidazoles as Inhibitors of Nitric Oxide Synthase.
First published: 10 June 2010
Abstract
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ChemInform Abstract
Guanidine-substituted imidazoles (III) and (VI) are prepared and evaluated as inhibitors of the three isoforms of nitric oxide synthase. While the presented results do not clearly identify a compound capable of binding simultaneously to the heme and guanidine binding sites of NOS, they reveal (IIIb) as a new isoform selective inhibitor.
