Heterocyclic Compounds
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ChemInform Abstract: Synthesis and Biological Characterization of SQBAzide, a Novel Biotinylated Photoaffinity Probe for the Study of the Human Platelet Thromboxane A2 Receptor.
First published: 10 June 2010
Abstract
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ChemInform Abstract
The synthesis and biological characterization of SQBAzide (VIII), a novel photoreactive derivative of the TXA2 receptor antagonist SQ31.491, is reported. The compound specifically inhibits human platelet aggregation mediated by TXA2 receptor activation and irreversibly labels platelet TXA2 receptors upon exposure to ultraviolet light.
