ChemInform Abstract: Synthesis of Two Stable Nitrogen Analogues of S-Adenosyl-L-methionine.
Abstract
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ChemInform Abstract
The homochiral syntheses of both title compounds, methylamine analogue (I) and previously unreported dimethylammonium analogue (II), are described. Compound (I) is a charge-switchable analogue of S-adenosyl-L-methionine whose ionic state is a function of the pH whereas the ionic state of compound (II) is pH-independent. The affinities of both analogues for a range of proteins are under investigation.
