ChemInform Abstract: Synthesis of Piperidine Analogues of 1-(3-Chlorophenyl)piperazine, a Well Known Serotonin Ligand.
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract
The synthesis of arylpiperideines (IV), (X) and arylpiperidines (V), (VI) is carried out. Piperideine analogues (IV) are obtained by dehydration while the N-unsubstituted compounds (X) are synthesized indirectly by a three-step sequence. Hydrogenation of piperideine (IVa) yields the piperidine (V) which is demethylated to give piperidine (VI). The corresponding pyridyl derivatives are prepared in a similar manner. Receptor binding assays show that (IVb) and (X) bind to both receptor subtypes.
