ChemInform Abstract: Nucleosides and Nucleotides. Part 188. A One-Pot Method for the Stereoselective Introduction of a Vinyl Group via an Atom-Transfer Radical-Cyclization Reaction with a Diphenylvinylsilyl Group as a Temporary Connecting Tether. Synthesis of 4′α-C-Vinylthymidine, a Potent Antiviral Nucleoside.
Abstract
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ChemInform Abstract
This offers a new and efficient method for the introduction of a vinyl group. It can be successfully applied to the synthesis of the vinyl nucleoside (XI).