Volume 30, Issue 20
Natural Products
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ChemInform Abstract: Total Synthesis and DNA-Cleaving Properties of Thiarubrine C.

Yamin Wang

Yamin Wang

Dep. Chem., Univ. Mich., Ann Arbor, MI 48109, USA

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Masato Koreeda

Masato Koreeda

Dep. Chem., Univ. Mich., Ann Arbor, MI 48109, USA

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Tonika Chatterji

Tonika Chatterji

Dep. Chem., Univ. Mich., Ann Arbor, MI 48109, USA

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Kent S. Gates

Kent S. Gates

Dep. Chem., Univ. Mich., Ann Arbor, MI 48109, USA

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First published: 15 June 2010

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract

The synthesis of the title compound (VII) is achieved via formation of the thioether (VI) and its cyclization. (VII) can produce DNA-cleaving reactive oxygen species under physiologically relevant conditions.

chemical structure image

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