ChemInform Abstract: Aminoalkanolic Derivatives of Xanthone with Potential Antiepileptic Activity.
Abstract
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ChemInform Abstract
The derivatives (V) are subjected to pharmacological screening. The exchange of the secondary amino group of (Va) for a tertiary one is generated by reductive N-methylation. The most promising compounds seem to be (Va), (Vb), and (VII). The former are active in both the anticonvulsant tests. The protective index in maximal electroshock (MES) for (Va) and valproate, as for (VII) and phenytoin or carbamazepine, is similar.
