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ChemInform Abstract: Synthesis of Oligonucleotides Containing 2′-Deoxyisoguanosine and 2′-Deoxy-5-methylisocytidine Using Phosphoramidite Chemistry.
First published: 20 June 2010
Abstract
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ChemInform Abstract
The solid phase synthesis of oligonucleotides containing 2′-deoxy-5-methylisocytidine and 2′-deoxyisoguanosine, which are of interest in DNA-based diagnostics, is presented. Various protecting groups for the phosphoramidates of these nucleotides in automated synthesis are evaluated. The N,N-diisobutylformamidine moiety is found to be a superior protecting group for 2′-deoxy-5-methylisocytidine.
