Volume 29, Issue 27
Natural Products
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ChemInform Abstract: Efficient Syntheses of (E)-5-(2-Bromovinyl)-2′-deoxy-4′-thiouridine; a Nucleoside Analogue with Potent Biological Activity.

I. BASNAK

I. BASNAK

Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK

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G. P. OTTER

G. P. OTTER

Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK

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R. J. DUNCOMBE

R. J. DUNCOMBE

Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK

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N. B. WESTWOOD

N. B. WESTWOOD

Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK

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M. PIETRARELLI

M. PIETRARELLI

Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK

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G. W. HARDY

G. W. HARDY

Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK

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G. MILLS

G. MILLS

Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK

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S. G. RAHIM

S. G. RAHIM

Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK

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R. T. WALKER

R. T. WALKER

Sch. Chem., Univ. Birmingham, Edgbaston, Birmingham B15 2TT, UK

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First published: 21 June 2010

Abstract

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ChemInform Abstract

Two efficient, alternative routes to the synthesis of the title thiouridine [cf. protected precursors (VII) and (X)], one of the most potent and selective antiherpesvirus compounds known, are developed.

chemical structure image

    The full text of this article hosted at iucr.org is unavailable due to technical difficulties.