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ChemInform Abstract: 7-Nitro-7-deaza-2′-deoxyadenosine and 8-Methyl-7-deaza-2′-deoxyguanosine: Pyrrolo[2,3-d]pyrimidine Nucleosides with Different Sugar Conformations.
First published: 23 June 2010
Abstract
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ChemInform Abstract
Based on 1H NMR spectroscopy and X-ray analysis it is found that the 7-nitro compound (II) adopts N-type sugar puckering conformation, whereas the 8-methylguanosine (III) shows S-type conformation. Despite the bulky methyl group in position 8, (III) exhibits anti conformation about the N-glycosylic bond.
