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ChemInform Abstract: C32-Amino Derivatives of the Immunosuppressant Ascomycin.
First published: 24 June 2010
Abstract
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ChemInform Abstract
Various C32-amino derivatives are investigated as replacements for the C32-hydroxyl group of ascomycin (I) and its C24-deoxy analogue. Substitution of the C32 hydroxyl group with the epimeric amino moiety, cf. compound (IV), leads to an approximate ten-fold loss in potency which is partially recovered with the removal of the C24 hydroxyl group, cf. compound (VII).
