ChemInform Abstract: Reactivity of Chiral Oxazaphospholidines on Activated Halide Compounds: Synthesis and Coordination Studies of Chiral Hybrid Phosphine—Phosphine Oxide Ligands.
Abstract
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ChemInform Abstract
Treatment of the oxazaphospholidine (I) with alkyl bromides of type (II) leads to phosphinamides with total diastereoselectivity. The reaction with α-haloacetophenones gives ketophosphinamides and diastereomeric vinylphosphonamides. Starting from the phosphinamide (IIIa) chiral hybrid phosphine—phosphine oxide ligands like (V) are prepared. (RP)-Benzylphenyl [2-(S)-diphenylphosphinomethylpyrrolidin-1-yl]phosphine oxide is found to act generally as a monodentate ligand in neutral metal complexes and as a bidentate ligand in cationic metal complexes. It is also applicable to the synthesis of heterobimetallic complexes.
