Heterocyclic Compounds
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ChemInform Abstract: Regio- and Diastereoselective Alkylation of 2-Substituted 2,4-Dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-diones.
First published: 24 June 2010
Abstract
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ChemInform Abstract
The alkylation of title compound (I) (related to the fungal metabolite 5-N-acetylardeemin, a potent reversal agent of multiple drug resistance in tumor cell lines) is investigated. Lithiation and electrophilic quench occurs regioselectively at the 1-position. The diastereoselectivity strongly depends on the alkyl halide (II).
