ChemInform Abstract: Synthesis and Heterocyclization of Allyl Derivatives of 8-Aminoquinoline.
Abstract
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ChemInform Abstract
The synthesis of 8-N-allylaminoquinolines is studied. The allylation of 8-aminoquinoline (V) gives a mixture of mono- and diallylamino derivatives (VI) and (VII) in ratios depending on the reaction conditions. Since products (VI) and (VII) are hard to separate, the formation of N-acetyl(tosyl)-N-allylaminoquinolines (III) is attempted. These derivatives are shown to cyclize very smoothly in the presence of iodine to form the pyrazino[3,2,1-i,f]quinolinium iodides (IV).
