ChemInform Abstract: Organic Nitrates. Part 2. Synthesis and Biological Activities of 4-Nitrooxymethylphenyl-1,4-dihydropyridines.
Abstract
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ChemInform Abstract
In order to obtain new vascular active substances synthetic procedures for 2-nitrooxymethyl-4-phenyl- and 4-nitrooxymethylphenyl-1,4-dihydropyridines, e.g. (V), are tested. The first ones are not available because of their spontaneous lactonization. The second type (V) is prepared by the Hantzsch reaction and found to be negative inotropic. The vasodilator activity of all derivatives is less than that of nitrendipine.
