ChemInform Abstract: Imidazo[2,1-b]thiazolium Salts on the Basis of 2-Phenylamino-4-methylthiazole.
Abstract
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ChemInform Abstract
Reaction of the aminothiazole (I) with phenacyl bromides proceeds regioselectively at the endocyclic nitrogen atom to give the N-(phenacylmethyl)substituted thiazoles (III) which on the action of dehydrating agents can undergo cyclization. Thus, in the presence of hydrobromic or formic acid the 2-arylimidazothiazole (VI) is obtained while under the action of propionic or acetic anhydride (IV) the 2-alkyl-3-phenacylimidazothiazoles (V) are formed.
