ChemInform Abstract: A Simple Preparative Method for 2-Alkylthiopyrroles.
Abstract
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ChemInform Abstract
Metalation of allyl isothiocyanate (I) with a mixture of LDA and KOtBu followed by successive quenching with water and methyl iodide leads to a high yield formation of the 2-alkylthiopyrrole (III). Omitting KOtBu during metalation gives the thiazole (IV) after quenching.