ChemInform Abstract: Palladium-Catalyzed Allylic Substitution in γ-Oxygenated Vinyl Sulfones: One-Step Synthesis of Tetrasubstituted Dihydrofurans.
Abstract
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ChemInform Abstract
A convergent and stereoselective one-step synthesis of highly substituted dihydrofurans by Pd(0)-catalyzed reaction of the carbonates of γ-hydroxy vinyl sulfones (III) with β-ketoesters and 1,3-diketones is described. Since vinylsulfones (I) can be readily prepared in enantiomerically pure form, this method should provide a general new access to enantiopure tetrasubstituted derivatives.
