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ChemInform Abstract: The Olefin Metathesis Approach to Epothilone A and Its Analogues.
First published: 02 August 2010
Abstract
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ChemInform Abstract
Aldol reaction and esterification coupling of the key building blocks ( I), (II), and (V) lead to the olefin metathesis precursors (VI) and ( VII). Starting from (VI) epothilone A (X) is obtained. Similar strategies with (VII) and further transformation of (IX) yield several analogues.
