ChemInform Abstract: Preparation of Fluorinated Galactosyl Nucleoside Diphosphates to Study the Mechanism of the Enzyme Galactopyranose Mutase.
Abstract
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ChemInform Abstract
The synthesis of two fluorinated galactosyl nucleoside diphosphates ( VIII) and (IX) using a novel latent → active phosphorylation strategy based on the isomerization of substituted allyl to vinyl glycoside (cf. (II) → (III)) and subsequent phosphorylation with dibenzyl hydrogenphosphate (IV) is given. Both synthesized diphosphates do not inhibit the enzyme galactopyranose mutase in the direction pyranose → furanose but both compounds inhibit the reverse reaction.
