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ChemInform Abstract: The Synthesis and Antifungal Activity of N-Alkylated Analogues of Echinocandin B.
First published: 02 August 2010
Abstract
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ChemInform Abstract
In continuation of earlier work the title analogues such as (I) are synthesized showing the importance of the rigid geometry of the side chain for improved in vitro antifungal activity. Only the N-acetylated compounds show a good in vivo activity.
