Heterocyclic Compounds
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ChemInform Abstract: Inhibition of Human Cytomegalovirus Protease by Benzoxazinones and Evidence of Antiviral Activity in Cell Culture.
First published: 02 August 2010
Abstract
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ChemInform Abstract
A series of 2-aminobenzoxazinones such as (VII) and (IX) is synthesized. The compunds potently inhibit human cytomegalovirus protease in vitro and show antiviral activity. By changing the substituent at the 6-position both enzyme selectivity and plasma stability can be modulated.
