ChemInform Abstract: Catalytic Conversions in Water. Part 5. Carbonylation of 1-(4- Isobutylphenyl)ethanol to Ibuprofen Catalyzed by Water-Soluble Palladium-Phosphine Complexes in a Two-Phase System.
Abstract
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ChemInform Abstract
The advantages of the optimized aqueous/organic biphasic synthesis of ibuprofen (III), using water-soluble Pd catalyst in the presence of TosOH, are facile catalyst separation, relatively mild non-corrosive reaction conditions, and avoidance of organic solvents, which has environmental benefits. However, the activity of this catalyst is diminished compared to the conventional Pd/PPh3 catalyst system, and further investigations are necessary to overcome this problem.
