Volume 28, Issue 48
Natural Products
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ChemInform Abstract: Synthesis of Analogues of 2-Methoxyestradiol with Enhanced Inhibitory Effects on Tubulin Polymerization and Cancer Cell Growth.

M. CUSHMAN

M. CUSHMAN

Dep. Med. Chem. Pharmacogn., Purdue Univ., West Lafayette, IN 47907, USA

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H.-M. HE

H.-M. HE

Dep. Med. Chem. Pharmacogn., Purdue Univ., West Lafayette, IN 47907, USA

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J. A. KATZENELLENBOGEN

J. A. KATZENELLENBOGEN

Dep. Med. Chem. Pharmacogn., Purdue Univ., West Lafayette, IN 47907, USA

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R. K. VARMA

R. K. VARMA

Dep. Med. Chem. Pharmacogn., Purdue Univ., West Lafayette, IN 47907, USA

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E. HAMEL

E. HAMEL

Dep. Med. Chem. Pharmacogn., Purdue Univ., West Lafayette, IN 47907, USA

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C. M. LIN

C. M. LIN

Dep. Med. Chem. Pharmacogn., Purdue Univ., West Lafayette, IN 47907, USA

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S. RAM

S. RAM

Dep. Med. Chem. Pharmacogn., Purdue Univ., West Lafayette, IN 47907, USA

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Y. P. SACHDEVA

Y. P. SACHDEVA

Dep. Med. Chem. Pharmacogn., Purdue Univ., West Lafayette, IN 47907, USA

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First published: 02 August 2010

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract

Among a series of 6-keto, -oximino, -hydrazono, and -amino derivatives, compounds (I), which have negligible estrogen receptor affinities, are of interest for in vivo investigation as anticancer agents, along with 2-ethoxyestradiol.

chemical structure image

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