Heterocyclic Compounds
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ChemInform Abstract: Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib).
Abstract
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ChemInform Abstract
Claisen condensation, followed by regioselective reaction with the hydrochloride of arylhydrazines yields almost exclusively 1,5- diarylpyrazoles. Among a series of derivatives, e.g. (I), (II), and ( III), only title compound (Ib) is of interest for further evaluation in clinical trials concerning treatment of rheumatoid arthritis and osteoarthritis.
