Isocyclic Compounds
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ChemInform Abstract: Dicarboxylic Acid Inhibitors of Phospholipase A2.
Abstract
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ChemInform Abstract
Ten diacids of type (III) are synthesized via a regio- and stereoselective aldol reaction. Models to rationalize the cis-cis olefin geometry are presented. All compounds display good to excellent antiinflammatory activity. Derivative (IIIa) is selected for further pharmaceutical development.
