ChemInform Abstract: Cycloaddition Reactions of a 3-(1,3-Butadienyl)cephalosporin and Antibacterial Activity of New Cephem Derivatives.
Abstract
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ChemInform Abstract
Cephem derivatives like (III) are obtained via (3 + 2) cycloaddition of the title compound (I) with various 1,3-dipolar reactants followed by deprotection. In the case of (III), methylation precedes deprotection. Diels-Alder reaction of cephem (I) with dienophiles affords, after deprotection, the corresponding cycloadducts of type ( II). (III) shows a good in vitro antibacterial activity and excellent in vivo efficacy.
