Volume 28, Issue 20
Natural Products
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ChemInform Abstract: A Novel Neuronal Cell Protecting Substance, Naphthomycinol, Produced by Streptomyces sp. PF7.

J.-S. KIM

J.-S. KIM

Inst. Mol. Cell. Biosci., Univ. Tokyo, Bunkyo, Tokyo 113, Japan

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K. SHIN-YA

K. SHIN-YA

Inst. Mol. Cell. Biosci., Univ. Tokyo, Bunkyo, Tokyo 113, Japan

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J. EISHIMA

J. EISHIMA

Inst. Mol. Cell. Biosci., Univ. Tokyo, Bunkyo, Tokyo 113, Japan

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K. FURIHATA

K. FURIHATA

Inst. Mol. Cell. Biosci., Univ. Tokyo, Bunkyo, Tokyo 113, Japan

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H. SETO

H. SETO

Inst. Mol. Cell. Biosci., Univ. Tokyo, Bunkyo, Tokyo 113, Japan

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First published: 04 August 2010

Abstract

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ChemInform Abstract

The title compound (I), a member of the naphthomycin series of antibiotics, decreases the L-glutamate toxicity in N18-RE-105 cells. It is assumed that the mode of action is not based on the antioxidative activity of (I).

chemical structure image

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