ChemInform Abstract: Indole Derivatives as a New Class of Steroid 5α-Reductase Inhibitors.
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract
A series of indole derivatives with varied substituents on the α, β-unsaturated double bond is synthesized and evaluated for their ability to inhibit rat prostatic 5α-reductase. The structure of the linking unit between the anilide moiety and indole skeleton is important in determining the activity. An ethyl instead of a methyl substituent results in enhanced inhibitory activity. Compound (I) shows the maximum potency with a 20-fold higher potency than the steroidal inhibitor MK-906.
