Preparative Organic Chemistry
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ChemInform Abstract: A Short Enantioselective Formal Synthesis of Methyl (S)-(-)-6,8- Dihydroxyoctanoate: A Key Intermediate for the Synthesis of (R)-(+)-. alpha.-Lipoic Acid.
First published: 04 August 2010
Abstract
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ChemInform Abstract
The enantioselective synthesis of ester (VII), a known intermediate in the total synthesis of the title acid (VIII), uses a novel retro-Henry reaction of the ω-nitro α,β-unsaturated ketone (II) and the kinetic enzymatic resolution of the oxo ester (IV) as key steps.
