Volume 28, Issue 13
Heterocyclic Compounds
Full Access

ChemInform Abstract: Asymmetric Reduction of a 1,5-Benzothiazepine Derivative with Sodium Borohydride-(S)-α-Amino Acids: An Efficient Synthesis of a Key Intermediate of Diltiazem (V).

S. YAMADA

S. YAMADA

Pharm. Dev. Res. Lab., Tanabe Seiyaku Co., Ltd., Yodogawa, Osaka 532, Japan

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Y. MORI

Y. MORI

Pharm. Dev. Res. Lab., Tanabe Seiyaku Co., Ltd., Yodogawa, Osaka 532, Japan

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K. MORIMATSU

K. MORIMATSU

Pharm. Dev. Res. Lab., Tanabe Seiyaku Co., Ltd., Yodogawa, Osaka 532, Japan

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Y. ISHIZU

Y. ISHIZU

Pharm. Dev. Res. Lab., Tanabe Seiyaku Co., Ltd., Yodogawa, Osaka 532, Japan

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Y. OZAKI

Y. OZAKI

Pharm. Dev. Res. Lab., Tanabe Seiyaku Co., Ltd., Yodogawa, Osaka 532, Japan

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R. YOSHIOKA

R. YOSHIOKA

Pharm. Dev. Res. Lab., Tanabe Seiyaku Co., Ltd., Yodogawa, Osaka 532, Japan

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T. NAKATANI

T. NAKATANI

Pharm. Dev. Res. Lab., Tanabe Seiyaku Co., Ltd., Yodogawa, Osaka 532, Japan

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H. SEKO

H. SEKO

Pharm. Dev. Res. Lab., Tanabe Seiyaku Co., Ltd., Yodogawa, Osaka 532, Japan

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First published: 04 August 2010

Abstract

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ChemInform Abstract

The title reduction of (IV) to give the key intermediate (I) in the synthesis of (V) is optimized.

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    The full text of this article hosted at iucr.org is unavailable due to technical difficulties.