ChemInform Abstract: Asymmetric Reduction of a 1,5-Benzothiazepine Derivative with Sodium Borohydride-(S)-α-Amino Acids: An Efficient Synthesis of a Key Intermediate of Diltiazem (V).
Abstract
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ChemInform Abstract
The title reduction of (IV) to give the key intermediate (I) in the synthesis of (V) is optimized.