ChemInform Abstract: Reaction of 3-Aroylmethylene-1,2,3,4-tetrahydroquinoxalin-2-ones with Lawesson′s Reagent and Biological Activity of the Reaction Products.
Abstract
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ChemInform Abstract
The reaction of the title aroylmethylene-quinoxalinone derivatives (I) with Lawesson′s reagent provides the corresponding arylthiocarbonyl derivatives (III) or 2-arylthiophenoquinoxalines (II) depending on the amount of the sulfuration reagent employed. While the first mentioned quinoxalines (III) show only low activity against St. aureus and E. coli strains, the cyclized products (II) show enhanced antimicrobial activity.
