ChemInform Abstract: Conformationally Constrained Serotonin Analogues: Stereoselective Synthesis of trans-3-(2-Aminocycloalkyl)indoles by Aziridine Ring Opening.
Abstract
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ChemInform Abstract
Trans-3-(2-aminocycloalkyl)indoles (III) are stereoselectively prepared by the nucleophilic ring opening reaction of the cycloalkylaziridines (II) and lower order magnesium cuprates generated from the corresponding indoles (I).