Volume 27, Issue 18
Natural Products
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ChemInform Abstract: Conformationally Constrained Serotonin Analogues: Stereoselective Synthesis of trans-3-(2-Aminocycloalkyl)indoles by Aziridine Ring Opening.

J. EZQUERRA

J. EZQUERRA

Cent. Invest. Lilly, S. A., E-28130 Valdeolmos, Madrid, Spain

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C. PEDREGAL

C. PEDREGAL

Cent. Invest. Lilly, S. A., E-28130 Valdeolmos, Madrid, Spain

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C. LAMAS

C. LAMAS

Cent. Invest. Lilly, S. A., E-28130 Valdeolmos, Madrid, Spain

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A. PASTOR

A. PASTOR

Cent. Invest. Lilly, S. A., E-28130 Valdeolmos, Madrid, Spain

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P. ALVAREZ

P. ALVAREZ

Cent. Invest. Lilly, S. A., E-28130 Valdeolmos, Madrid, Spain

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J. J. VAQUERO

J. J. VAQUERO

Cent. Invest. Lilly, S. A., E-28130 Valdeolmos, Madrid, Spain

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First published: April 30, 1996

Abstract

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ChemInform Abstract

Trans-3-(2-aminocycloalkyl)indoles (III) are stereoselectively prepared by the nucleophilic ring opening reaction of the cycloalkylaziridines (II) and lower order magnesium cuprates generated from the corresponding indoles (I).

chemical structure image

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