Volume 27, Issue 18
Natural Products
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ChemInform Abstract: A Convergent Total Synthesis of the Multidrug Resistance-Reversing Agent Hapalosin.

T. Q. DINH

T. Q. DINH

Dep. Chem. Biochem., Univ. Calif., Los Angeles, CA 90095, USA

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R. W. ARMSTRONG

R. W. ARMSTRONG

Dep. Chem. Biochem., Univ. Calif., Los Angeles, CA 90095, USA

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First published: April 30, 1996

Abstract

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ChemInform Abstract

The key steps in the synthesis of the title compound (XII) are stereoselective allylboration of the aldehydes (III) and (VI) and macrolactonization of the hydroxyacid (XI).

chemical structure image

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