Volume 27, Issue 16
Natural Products
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ChemInform Abstract: Total Syntheses of (+)-Acutiphycin (Ia) and (+)-trans-20,21- Didehydroacutiphycin (Ib).

A. B. III SMITH

A. B. III SMITH

Dep. Chem., Univ. Pa., Philadelphia, PA 19104, USA

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S. S.-Y. CHEN

S. S.-Y. CHEN

Dep. Chem., Univ. Pa., Philadelphia, PA 19104, USA

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F. C. NELSON

F. C. NELSON

Dep. Chem., Univ. Pa., Philadelphia, PA 19104, USA

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J. M. REICHERT

J. M. REICHERT

Dep. Chem., Univ. Pa., Philadelphia, PA 19104, USA

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B. A. SALVATORE

B. A. SALVATORE

Dep. Chem., Univ. Pa., Philadelphia, PA 19104, USA

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First published: April 16, 1996

Abstract

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ChemInform Abstract

The macrolides (I) of significant in vivo antineoplastic activity and cytotoxicity are prepared similarly. A key step is represented by the highly stereoselective hydrozirconation-bromination of (IV).

chemical structure image

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