ChemInform Abstract: Total Syntheses of (+)-Acutiphycin (Ia) and (+)-trans-20,21- Didehydroacutiphycin (Ib).
Abstract
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ChemInform Abstract
The macrolides (I) of significant in vivo antineoplastic activity and cytotoxicity are prepared similarly. A key step is represented by the highly stereoselective hydrozirconation-bromination of (IV).